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STEVIA REBAUDIANA BERTONI 6- ........................................................................................ .., .., .., .., .. STEVIA REBAUDIANA BERTONI................................................................................................... .., .. .............. , , .., ..

................................................................................................. .., .., .. .............................. .., .., .., ..

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................. .., .., .., .., .., .., .. N'{N-[3--20(29)-͖28-]-9-} 3--3-- ........................................ .., .., .., .., .., .., .. - ...... .. ..................................................... .. CHAMERION ANGUSTIFOLIUM (L.) HOLUB................. .., .., .. (.), .., .., .., ..

.......... .., .., .., .., .., .. ............................................................................................ .., .., .., .., .., .. ......................................................................................... .., .., .., .. ...................... .., .. FERULA VARIA......... .., .., .. ........................................................................................................ .., .. ........................................................... .., .. HYPERICUM PERFORATUM L. .......................................................................................... .., .., .. - ................................................. .., .. ..................................................





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.......................................................................... .., .. .......... .. ..................................................... .., .., .. ............................................................................................

.., .., .. ......................... .., .., . ELAEAGNUS ANGUSTIFOLIA L................................................................... .., .., .. AGRIMONIA EUPATORIA L., FILIPENDULA VULGARIS MOENCH, ANTHEMIS ARVENSIS L. ARTEMISIA ......................................................................... .. .................................................................................................... .., .. - .................................................................................................... .., .., .. (THYMUS SERPYLLUM L.), ............ .. .......................... .., .. - ........................................................ .., .., .. (POLIGONUM ALPINUM ALL.)............................... .., .. .................................................................................... .., .. (ROSA L.), ....................................................................................................... .., .., .., ..

- , »..................................................................................................... .. (FEIJOA SELLOWIANA BERG) ...................... .., .. HEDYSARUM L. ................... .., .., .., .., .. ................................................................................................. .., .., .., .., .. GENTIANA MACROPHYLLA............................................................................................................... .., .., .. . CARYOPHYLLACEAE.. .., .., .., .., .. - RHODODENDRON ADAMSII REHDER......................................................... .., .., .., .., .. ................. .., .., .., .., .. INONOTUS OBLIQUUS......................................................... .., .., .., ..

PINUS SIBIRICA DPPH ....................................................... .., .., .., ..

.................... .., .., .., ..

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.., .. , .............................................................................. .., .., .. ARTEMISIA PONTICA L. ........................ .. ................................................. .. ۻ............................................................................... , .., .. ............... .., .. - ......................................................................................... .., .. ...........................................................................

.., .., .. ....................... .. ............................................................................................ .., .. TRIFOLIUM PRATENSE L...... .., .. ............................ .., .. .................................. .., .. .......................................... .., .. , .............................................................................................. .., .., .., .., .., .., .., ..

............................................................... .., .., .. SOPHORA FLAVESCENS AIT........... .. .., .. THYMUS TALIJEVII .................................................. .., .., ..

4- ............................................................... .., .., .., .., .. ............................................ .., .., .., .., .., .., .., .. ALFREDIA CERNUA CASS. , ......... .., .., .., ..

, ....................................................... .., .. ............................................................................

.., .. HIPPOPHA RHAMNOIDES L..................... .., .. (ARTEMISIA ABSINTHIUM L.) .........................................................

.., ., ., ., .. , ............................................................................................................... .., .. , ...........................................................................

.., .., .. ............................................................................................ .., .. CETRARIA ACH........................................................................................................ .., .., .., .., .., .., .. -: .................................................................................................... .., .., .., .., .., .., .. ...................... .., .., .. ..................................................................... .., .., .., .., .. , ............... .., .., .., ..

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II. , , , .. . . , . , 2, 236040 () E-mail: Plem-kant@yandex.ru : ( ) ( ). , , , .

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R R R R N N ( II ) H (I) , , , ( , , III). (IV).

O HN O ( IV ) N ( III ) CH . ( , , ..), , , : , , , . - ( 3).

OH OH HO O O R OH O O HO O O O Ph O , , , , , - ( 4).

OH O O N O N N OH O N N R RO ;

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.. 1, .. 2, .. , . , 28, , 630126 () E-mail: sapronova@ngs.ru . .. , 9, , 630090 () , . , 2, , 630090 () . , , , . .

(1), (2), 3- (3), - (4), [1] -: 3--6- (5), 2,2--3-(2-)- (6) 2,2--3- (7).

O O O O CN CN CN 1 2 3 4 5 6 57 ( ) , 6 , 9 10, 5 - 8.

O CN CN 5 [H] O CN CN O CN CN 7 - . (2) . , 11 60%. 11 12 , . ( 20% ) .

OH (H3C)2C O O CN CN [H] CN 1 11 11 13 16, . 13 . , (-) , 13 80%, 16 . 13 16 O- 14 17, 14 , 15. 1115 13 16 O- , 15 22% 11.

TsO CN CN HO CN TsCl O CN 13 TsO CN HO CN TsCl 16 , .

1. Thachev A.V., Rukavishnikov A.V., Chibirjaev A.M., Volodarsky L.B.

Conversion of terpenic compounds to -ketonitriles // Synthetic Communi cation. 1990. V. 20. 14. P. 21232132.

N- .. , , () E-mail: compounds@intal.uz , , . [1]. [23].

, 3,7-, [4]. , [4]. N- :

R N O NH RCOCI N N Et3N O O R CH(CH3)2 CH2CH(CH3)2 C(CH3)3 CH=CHCH (1) (2) (3) (4) CH2CI CH2Br CHCICH3 CHBrCH (5) (6) (7) (8) H3C H3CO CH2OHCICH3 CCI (9) (10) (11) (12) CI H N O CI O (13) (14) (15) (16) , . 6078%.

-, -, . 116 - 16451660, 15301550 -1, 16801695 -1. 116 - 6,156,30 7,16 .., , 7,17,3 .. . .

[] 20D , - . N- 1-16 -HIV CEM-SS 5,00105 [5] Mycobacterium tuberculosis H37Rv 12,5 g/ml in vitro [6].

1. .., .., .. . ., 1975. . 5464.

2. .., .. . N // .

2001. 4. . 301305.

3. .., .., .. - // . 2002. 4. . 288289.

4. .. . ., 1998. . 1. . 127.

5. Weislow O.W, Kiser R, Fine D. ed al. New soluble-formazan assay for HIV-1 cytopathic effects;

application to high-flux screening of Synthetic and natural products for AIDS-antiviral activity // J. Nate. Cancer Inst.

1989. V. 81. P. 577586.

6. ollins L., Franzblau S.G. Microplate Alamar Blue Assay versus BACTEC 460 System for High-throughput Screening of Compounds against Myco bacterium tuberculosis and Mycobacterium avium // Antimicrob. Agents Chemother. 1997. V. 41. P. 10041009.

- .. , .. , .. , .. , . , 71, , 450054 () E-mail: insect@anrb.ru H2O2, , , . [1], , .

- (- , ) [2] 1 2, .

THF [3]. 1 2 H2O2 1,3-(3), (4) 1,4-(5), (6) .

OH 1. NaBH4, BF3OEt Me(CH2)5 (CH2)7R 2. H2O2, NaOH 91-99% 1 R = Me 2 R = CH2OH OH OH OH (CH2)7R (CH2)7R R,S + Me(CH2)5 Me(CH2) R,S OH SR SR 3 R = Me 5 R = Me 4 R = CH2OH 6 R = CH2OH 3 5 1 55 45% . -(7R,10RS)- 5 7:3, . 1,4- 5 -10 5 2,5- /- 7 5 (7 : 3) TsOH [4].

TsOH/C6H6, 2 5 Me(CH2)5 (CH2)7Me O quant.

7 -2 -5, - CH2- -2 - - , -, 2 2,5 .. . - [58] 2,5- , [9] .

1,3- 1,4- [1013], [5, 14] .

[4] 5 (R)- . 13 7 (7:3) (dl)- .. -2 -5, -CH2- -2 5, .. -2 -5, ()- 7. - (2R,5R)- (2S,5S) 7 [14]. , (R)- -7 1, -10 (S)- . ()- 7 (R)- (S) -2 -5, (R,R)-, dl- . 70%, dl- 30%.

2 -, 1, -(1,10RS,12R)- 4 (53%) -(1,9RS,12R)- 6 (47%).

[12, 13] 1,3- 4 ,/,- 1,3- 8.

Ph O 2O PhCHO, ZnCl2, 4 +6 6 + R,S (CH2)8OH Na2SO4 Me(CH2) 8 SR - 2 1,3- 1,4-. , 1,3- 8 [12, 13, 15] 1,3- , [16]. .. Ph- (5,56 ..) [17, 18]. 1 , .. -2 (, 100,57 ..), -4, -6 (, 77,10 ..), , ,- . (R)- -12 ()--4, -6 -4 (S) . .. - (, 99,1 ..), -4 (, 71,34 ..), -6 (, 77,92 ..) ()--4, -6 , -2 .

-4 (R)-. , ()- , ()- 75 25% (10S,12R)- 4, 1,3-.

1,3- 3 66 : 34, 6 61:39. 1,3- 1,4 3 5 4 6, , , (S)- .

, , - , . 2 .

1. .., .. . ., 1977. 516 .

2. .., .., .., .. .

// . 2005. 6. . 529534.

3. Schlesinger H.I., Brown H.C., Hoekstra H.R., Rapp L.R. Reactions of diborane with alkali metal hydrides and their addition compounds. New syntheses of borohydrides. Sodium and potassium borohydrides // J. Amer.

Chem. Soc. 1953. V. 75. 1. P. 199204.

4. Reppe W. thinylierung // Liebigs Ann. Chem. 1955. Bd. 596. S. 1224.

5. Mihailovic M.Lj., Mamuzic R.I., Zigic-Mamuzic Lj., Bosnjak J., Cekovic Z. Assignment of cis-trans configuration to constitutionally symmetrical 2,5-dialkyl-tetrahydrofurans // Tetrahedron. 1967. V. 23. 1. P. 215226.

6. Pilli R.A., Riatto V.B. Diasteroselective synthesis of 2,5-disubstituted tet rahydrofuran derivatives // Tetrahedron: Asymmetry. 2000. V. 11. 18.

P. 36753686.

7. Yoda H., Mizutani M., Takabe K. An efficient and stereoselective conver sion of lactones to substituted cyclic ethers // Heterocycles. 1998. V. 48.

4. P. 679686.

8. Shi H., Liu H., Bloch R., Mandville G. A novel efficient and stereoselec tive synthesis of cis- or trans-2,5-disubstituted tetrahydrofurans // Tetrahe dron. 2001. V. 57. 45. P. 93359341.

.. 1 13 9.

. . . . . , 1985. 104 .

10. .. . ., 1998. 464 .

11. Dounay A.B., Florence G.J., Saito A., Forsyth C.J. Direct synthesis of sub stituted tetrahydrofutans via regioselective dehydrative polyol cyclization cascades // Tetrahedron. 2002. V. 58. 10. P. 18651874.

12. Sharma M., Brown R.K. The preparation of 4,6-O-benzylidene-D-glucal and the reaction of methyllithium with methyl 2,3-anhydro-4,6-O benzylidene--D-allopyranoside // Canad. J. Chem. 1966. V. 44. 23.

P. 28252835.

13. Kuzuhara H., Ohrui H., Emoto S. Synthesis with azido-sugars. 2. Conver sion of D-glucose to (+)-desthiobiotin // Agr. and Biol. Chem. 1971. V. 35.

1. P. 817.

14. Mihailovic M.Lj., Gojkovic S., Cekovic Z. Stereochemistry of cyclic ether formation. Part I. Stereoselective intramolecular cyclisation of aliphatic disecondary 1,4-diols and their sulphonate esters tetrahydrofurans // J.

Chem. Soc. Perkin Trans. Part I. 1972. 22. P. 24602464.

15. .., .., .., .. . ., 1984. 288 .

16. Eliel E.L. Conformational analisis in heterocyclic systems. Recent results and applications // Angew. Chem. 1972. Bd. 84. 17. P. 739750.

17. .., .., .., .. .

(, , ) 2--1,3-. // .

1998. . 68. . 1. . 140146.

18. C .. . , 1978. . 1. 205 .

- , , , .. , .. , .. , .. , .. , .. , .. . .. , . , 8, , 420088 () E-mail: kataev@iopc.knc.ru ( 04 03-32133).

(-16--19- ) 1, Stevia rebaudiana Bertoni [1], ( [2], [3], [4]), - 2 [5]. , - 2 .

- , , . , .

, - 2, [5], 35, 46%.

-, 1 - (MALDI). , 3.

O O (CH2)n O O (CH2)n O O O O O O CO2H CO2H CO2H O O 1 2 n = 4 (3), 6 (4), 8 (5) 5 , , 6. CCl4, 79 16, 33 26% . - . - ( 7 9, MALDI 8). 9 .

OH O O (CH2)n O CH O CH O O O CH CH CH CH H2C O CH CH2OH O CH CO2H H2C O (CH2)n CH O O O 1 6 n = 1 (7), 4 (8) , 1 , , [6], 10. 1 10 (R= OH). 1 23% - 12. , 1 , - 11, . 10 (R= OH).

N N O O 1. SOCl N2H 2. ROH CO CH3OH CO OH OR C C O O OR OR O O N-NH-C-(CH2)n-C-NH- N CO OC n = 1 (11), 4 (12) OH OH 13 ( 1 ) 1 : 1 54% 14. 20- 13. 25% , - MALDI 15. .

O O 1: O ( 14 ) NH HN C C N2H4 O O CO O N N N NH C Cl ( 13 ) 1 : C C C O NH NH O N O NH ( 15 ) 13 CCl4 16, 35% 17.

13 . 25% 18. 13 , 32%, 19. - - 18 (1693 -1) 1737-1. - 19 , 1665 -1, C=N II 1528 -1. - () .

N NHC(O)CH2C(O)HN N O O O CO C O (CH2)2 O C C O (CH2)2 O C Cl O O O O 16 O O ( 18 ) C NHNHC(O)(CH2)4C(O)HNHN C O O O N NHC(O)(CH2)4C(O)HN N CO Cl ( 19 ) ( 13 ) C NHNHC(O)(CH 2)4C(O)HNHN C O O 1. .. . // . 1998. . 68. . 11. . 18131821.

2. Lee . et al. // Planta Med. 2001. Vol. 67. P. 796799.

3. Chen S., et, al. // Int J. Cardiol. 2004. Vol. 97. 2. P. 175.

4. Kelmer Bracht A., et al. // Pharmacol. Biochem. 1985. V.. 34. 6. P. 873882.

5. .. . // . . . 2006. . 40. . 9. . 1213.

6. Paulsen H. et al. in The chemistry of Hydrazo, Azo and Azoxy Groups, ed. S.Patai, Interscience. New York. 1975. V. 2. Ch. 10. P. 527532.

STEVIA REBAUDIANA BERTONI 6- .. , .. , .. . .. , . , 8, , 420088 () E-mail: kataev@iopc.knc.ru 20 , - Stevia rebaudiana Bertoni [1], 1, 2, , , [2], , 1, ( Sweta [3]).

O CO2H CO CH2OH O HO OH OH O CH2OH O CH2OH O O HO HO OH OH O CH2OH O CH2OH O O HO HO OH OH OH OH 2 [4], [5].

, 2 2030% 3 6. 70 . 36 -, 1- - ().

O C OR (3) CH (4) (CH2)2O O CH2OH O Cl HO OH H3C O CH 2OH n = 4 ( 5 ), 6 ( 6 ) O (CH2)n N O HO N O OH CH OH 2 [6], , , Stevia rebaudiana Bertoni [7].

2 1,9- 5% ( ) 7.

O O C C (CH2) O HOCH2 O CH2OH O O HO OH OH OH HOCH2 O O CH2OH O O HO OH OH OH OH OH 1. .. // . 2004. 12. . 6165.

2. Philips K.C. // Developments in Sweeteners/ Elsevier, London, 1989. V. 1.

3. www.stevian.ru, www.greenlite.ru 4. DuBois G.E., Stephenson R.A. // J. Med. Chem. 1985. V. 28. 1. P. 9398.

5. Lin L.-H., Lee L.-W., Sheu Sh.-Y., Lin P.-Y. // Chem.Pharm.Bull. 2004.

V. 52. 9. P. 11171122.

6. Mosettig E., Nes W.R. // Organic chemistry. 1955. V. 20. 7. P. 884890.

7. .. . // . 1998. . 68. 11. . 18131821.

8. .., .. . // . 2007, .

STEVIA REBAUDIANA BERTONI .. , .. , .. , .. , .. . .. , . , 8, , 420088 () E-mail: kataev@iopc.knc.ru , Stevia rebaudiana Bertoni [1]. () (13----16--19- ). , 1 , ( [2], [3], [4] .). . [2, 5]. , , 1 ( 16 -) 2 (-16--19- ).

3 H 3C 10 11 5 19 6 7 CH O OH CH 3 O OH O OH 1, .

1 (NaIO4) Sweta, Stevia rebaudiana Bertoni [6], [7].

, , 1 16. ( 1). 1 [2], ( ). 20% , []20D = 40 ( 0.38, CHCl3) . . = 190 .

H3 C H3C CH3 O O O OH CH3 OH CH H OH OH 3 H3C CH2OH O OH CH O [2] 16(S) , , []20D = 28.2 ( 0.43, CHCl3), . . = 190 192 , 16(R)-, , []20D = 110.9 ( 0.33, CHCl3), . . = 216218 , , 16(S) 3, . 3 4, 10 16.

4, 1 [2]. , -, 17- 5, [5]. 4 1,5% - 6, 5. 2 2,68 .., 15, 3,51 3,64 .., 17- 5, 4, 5.

4 -3 . - m/z 409, 391, 79.

H 3C H 3C CH2OH CH2NH(CH2)3OH O O OH OH CH3 OH CH OH OH OH H3C CH2NH(CH2)3OH H 3C CH2NH(CH2)3OH O OH NH CH O OH CH (CH2)3 OH O OH 0.901.35 .., 1 2, . 1 -, - 79.

- - 15,17- 11. , (10), 15 , [8]. [8], 15(S) 11 1 2,6 .., 15, (4.54 ..) 15, .

H 3C H 3C H 3C O CH2Br CH2Br Br O OH CH3 O O OH CH3 OH CH isoniaside O OH O Br 4 1 , , - -. - 1 , 2 [9]. 1 - [9], 35% 12. 1665 -1 (=CH2) 3485 -1 (O-H), 1701 -1. 1 5.01 5.14 .., , 7.36 .., . 12 m/z 408 [M]+ , (m/z 390 [M-H2O]+) (m/z 317 [M-CH2C6H5]+).

H 3C PhCH2Br CH O O CH CH ( 12 ) OH H3C CH2 CH CH O OH CH HO OH OH (1) Br(CH2)9Br CH3 H3C ( CH2 ) O O CH3 O O CH ( 13 ) 1 1,9- 18% - 13, , -.

, 1, 16(S)- 3 16,17 4. , , 1 - -.


1. .. // . 2004. 12. . 6165.

2. Pezzuto J.M. et al. // Proc. Natl Acad. Sci USA. 1985. V. 82. P. 24782482.

3. Lin L.-H., Lee L.-W., Sheu Sh.-Y., Lin P.-Y. // Chem.Pharm.Bull. 2004.

V. 52. 9. P. 11171122.

4. Boonkaewwan, C. et al. // J.Agric.Food Chem. 2006. V. 54. P. 785789.

5. Avent A.G. et al. // J. Chem. Soc. Perkin Trans 1. 1990. P. 26612665.

6. www.stevian.ru, www.greenlite.ru 7. .. . // . 1998. . 68. 11. . 18131821.

8. .. . // . 2005. . 75. . 622628.

9. .. . // . 2007, .

.. , .. . .. , . , 1, () E-mail: zoya@irk.ru , , , , . , . .

[1], - . : ( -2 -6). , , -.

H H H O O OH OH O OH H H CH2OH CH2OR H N H H H O O HO HO O HO H H H O O O OH OH OH H2C H2C H2C HO HO TosCl HO NaN H H H O O O O O O OH OR OR H H H H H H n n n Tos = H3C S O R= H or Tos ( 5060 ) 224 . , . , - 1 13 . N3- 13 50.9 (-6-N3), 63.5 (-2-N3) 104.2 .. (-1--2-N3).

-, , .

1. Liu C., Baumann H. // Carbohydrate research. 2002. V. 337. P. 12971307.

1, 1, .. 2, .. , , 16, , 210042 () E-mail: raoxiaoping1978@yahoo.com.cn , ., 85, . , () E-mail: radlesma@sandy.ru , . , . , . ().

- C26H33NO 139,2 .

- (KBr, -1): 3335(N-H), 2956, 1650 (O=C-N), 1525, 1384, 749.

1 - (CDCl3, /m, 300 M): 7.28 (1H,CONH-);

7.56 6.90 (8H,C=CH-);

2.85 (1H,-CH(Me)2);

2.931.61 (10H,-CH2-);

1. (1H,CH-);

1.44-1.25 (12H,CH3) , . XRD Enraf-Nonius CAD-4 c Mo Ka (=0.07103) 293. , , . - F2. , . SHELXS97, SHELXL97. 1. 2.

, ( P212121). 1, : ( C4C9), B ( C7C9, C10C13), C ( C12C17) D ( C21C26). B C . , C B , . - (C18 C19) . D . , , (. 2), , .

1. C26H33NO 375, 293(2) K 0, Space P a () 5,9750 (12) b () 10,931 (2) c () 33,179 (7) () 90, () 90, () 90, V (3) 2167,0(8) () (/3) 1, (-1) 0, F (0 0 0) 0,40 0,20 0, () 1,23 26,96 0h7, 0k13, 0l =25.99 99,9% . . 0,9731 0, // 2731/0/ F2 1, R [I2(I)] R1 = 0,0775, wR2 = 0, 0 (10) 0,188 -0,275 e,A- R1=F0Fc/F0;

wR2=[w(F20F2c)2/[w(F20)2]1/ . 1. ORTEP , 2. , NC20 1,371 (7) NC21 1,401 (7) OC20 1,230 (7) C1C3 1,518 (9) C3C4 1,525 (8) C7C13 1,527 (7) C8C9 1,403 (8) C8C10 1,496 (7) C13C18 1,588 (7) C14C15 1,520 (7) C21C26 1,384 (8) C24C25 1,397 (11) , C20NC21 129,1 (6) C9C4C3 121,1 (6) C5C4C3 122,3 (6) C6C7C13 119,5 (5) C8C10C11 114,1 (5) C10C11C12 109,9(5) C14C13C18 108,6(5) C15C14C13 113,5(5) C20C17C19 111,9 (5) OC20N 120,8 (6) OC20C17 121,1 (6) NC20C17 118,1 (5) C22C21C26 119,4 (6) C22C21N 122,4 (6) C26C21N 118,2 (6) C26C25C24 120,3(7) , C5C6C7C13 177,3 (5) C13C7C8C9 176,9 (5) C6C7C8C10 178,2 (6) C13C7C8C10 4,2 (9) C9C8C10C11 166,0 (5) C8C10C11C12 44,5 (7) C10C11C12C17 159,2 (5) C6C7C13C12 163,9 (5) C11C12C13C18 66,0 (6) C17C12C13C18 69,5 (6) C15C16C17C12 50,6 (7) C15C16C17C19 73,3 (7) C11C12C17C19 62,0 (7) C13C12C17C19 71,3 (7) C21NC20O 4,6 (10) C21NC20C17 173,6 (5) C22C23C24C25 0,1 (12) NC21C26C25 178,1 (6) .2. .. , .. , .. - , . , 2, 4, , () E-mail: radlesma@sandy.ru - , - , , .

, :

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2--1 ();

-2- ( );

;

H2SO4, H3PO4, HlO4, () H4SiW12O40 H7PW12O42. , . , , H2SO4:

CH H3C CH CH k + CH3 OR ROH k- CH , () ( ) () :

N z 2 e2 1 ln k = ln k 0 + ( ), 2 R T r r k0 =, ze , r r . , ( ). rr, .

. , , . 1 2.

. 1. - . 2. - - H2SO4 (30 60 ) - PW12 (30 60 ) .. , .. , .. , .. , . 42, , 660049 () E-mail: zenav@mail.ru , ( , , , .). . 250 . . , [1]. . , .

3,28- 20(29)-(1) . :

CH H2C CH3 CH3 CH2OCOCH CH CH3COO H3C CH .

, . . [2].

, , , 30- [3].

, . , , [4]. 14 . , . , . : : .

- . 46 . 93% . , .

.

. . . . 35% ..

. , 98%. 225 .

.

( 13 ) ( 310 ) . , . .. 3538%.

92% 94% .

- : 1 (.).

1-(CDCl3):

4,72 (1, , =2);

4,55 (1, , =2);

4,47 (1, , 3);

4,26 (1, , J10,7 , 28);

3,86 (1, , J10,7 , 28);

2,50 (1, , 19);

2,08(3, , 3);

2,03 (3, , 3);

1,65;

1,02;

0,94;

0,82;

0,80 ( 3, , 3).

, % [C34544], % C 80,5 9,5 10,0 77,5 10,3 12, , , .

1. .., .., .. . . // - . 2002. . 36. 9. . 2628.

2. .., .., .. . // . .

. 1993. . 56. 4. . 53 3. US 7041701. Triterpenoid derivatives. 09.04.2006.

4. .., .., .. , // . 1998. 1. . 59.

.. 1, .. , . ,79, , 660041 () E-mail: kogay@lan.krasu.ru , , , 660036 () . -. (, , , ..) [1, 2], .

. , 3,28--- --1 [1]. [2].

, [3, 4].

. - .

1- , , - . , [5] . 0 20 ( 1).

1 : Silufol UV-254 (100 : 2 : 0,5). . . . , . - , .

RCOCl CH2OH C5H5N, C6H HO O CH2O-C R R2O R = 1--;

(2-)-;



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